NH(3)-dependent NAD(+) synthetase

BE0001601ProteinBacillus subtilis (strain 168)nadE

Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. It is acted on by 3 drugs in DrugBank.

Gene name
nadE
UniProtKB entry
P08164Swiss-Prot
Residues / weight
272 residues · 30,395 Da
Also known as
6.3.1.5 · General stress protein 38 · GSP38 · outB · Spore outgrowth factor B

Resolves to

Protein
UniProtP08164UniProt nameNADE_BACSU
Gene
NCBI Gene938339GenBank143279
Pharmacology
KEGGbsu:BSU03130
Structure
PDB1EE1PDB1FYDPDB1IFX
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NH(3)-dependent NAD(+) synthetase, how selective are they, and which programs against it are still in active trials?

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