Accession Number

A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1a, obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation).

Small Molecule
Approved, Vet approved
Average: 477.5954
Monoisotopic: 477.316248755
Chemical Formula
  • Gentamicin
  • Gentamicina



For treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indole-positive and indole-negative), E. coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative).

Associated Conditions
Contraindications & Blackbox Warnings
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Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

Mechanism of action

Aminoglycosides like gentamicin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

A30S ribosomal protein S12
Escherichia coli (strain K12)
A16S ribosomal RNA
Enteric bacteria and other eubacteria
NLow-density lipoprotein receptor-related protein 2
UNH(3)-dependent NAD(+) synthetaseNot AvailableBacillus subtilis (strain 168)
UDihydrofolate reductaseNot AvailableHumans

Injections lead to peak serum concentrations in 30-60 minutes. Topical gentamicin is readily absorbed from large burned, denuded, or granulating areas but not through intact skin. Absorption of gentamicin is faster and greater with the cream compared to the ointment. Gentamicin is absorbed in small quantities following topical application to the eye. Gentamicin is also absorbed in small amounts following topical application to the ear (especially if the eardrum is perforated or if tissue damage is present). Gentamicin is very poorly absorbed orally.

Volume of distribution
Not Available
Protein binding

Low (between 0 and 30%)

Not Available
Route of elimination
Not Available

3-3½ hours in infants one week to six months of age; this increases to 5½ hours in full-term and large premature infants less than one week old.

Not Available
Adverse Effects
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Mild and reversible nephrotoxicity may be observed in 5 - 25% of patients. Gentamicin accumulates in proximal renal tubular cells and causes cell damage. Tubular cell regeneration occurs despite continued drug exposure. Toxicity usually occurs several days following initiation of therapy. May cause irreversible ototoxicity. Otoxocity appears to be correlated to cumulative lifetime exposure. Drug accumulation in the endolymph and perilymph of the inner ear causes irreversible damage to hair cells of the cochlea or summit of ampullar cristae in the vestibular complex. High frequency hearing is lost first with progression leading to loss of low frequency hearing. Further toxicity may lead to retrograde degeneration of the 8th cranial (vestibulocochlear) nerve. Vestibular toxicity may cause vertigo, nausea, vomiting, dizziness and loss of balance. Mouse, intravenous LD50: 52 mg/kg; rat, intravenous LD50: 96 mg/kg.

Affected organisms
  • Enteric bacteria and other eubacteria
  • Pseudomonas aeruginosa
  • Yersinia pestis
  • Francisella tularensis
  • Serratia marcescens
  • Proteus vulgaris
Gentamicin Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available


Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
AbacavirGentamicin may decrease the excretion rate of Abacavir which could result in a higher serum level.
AcarboseGentamicin may decrease the excretion rate of Acarbose which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Gentamicin which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
AcenocoumarolThe risk or severity of bleeding can be increased when Gentamicin is combined with Acenocoumarol.
AcetaminophenGentamicin may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
AcetylcholineThe therapeutic efficacy of Acetylcholine can be decreased when used in combination with Gentamicin.
AcetyldigitoxinThe risk or severity of adverse effects can be increased when Gentamicin is combined with Acetyldigitoxin.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.
AclidiniumGentamicin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Additional Data Available
  • Extended Description
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  • Severity
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  • Evidence Level
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Food Interactions
No interactions found.


Product Ingredients
IngredientUNIICASInChI Key
Gentamicin sulfate8X7386QRLV1405-41-0Not applicable
International/Other Brands
Alcomicin / Bristagen / G-Mycin / Genoptic (Allergan) / Gentacidin / Gentafair / Gentamar / Jenamicin / Ocu-Mycin / Spectro-Genta / U-gencin (U-Liang)
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Alcomicin Oph Sol 3mg/mlLiquidOphthalmicAlcon, Inc.1983-12-312009-04-24Canada flag
Cidomycin Inj 10mg/mlLiquidIntramuscular; IntravenousHoechst Roussel Canada Inc.1995-12-312000-07-28Canada flag
Cidomycin Inj 40mg/mlLiquidIntramuscular; IntravenousHoechst Roussel Canada Inc.1995-12-311999-08-20Canada flag
Cidomycin Inj 40mg/mlLiquidIntramuscular; IntravenousRoussel Canada Inc.1979-12-311997-08-05Canada flag
Cidomycin Inj Pediatric 10mgLiquidIntramuscular; IntravenousRoussel Canada Inc.1972-12-311997-08-05Canada flag
Garamycin Cream 0.1%CreamTopicalSchering Plough1966-12-312007-08-03Canada flag
Garamycin Inj 10mg/ml PediatricSolutionIntramuscular; IntravenousSchering Plough1970-12-312004-07-21Canada flag
Garamycin Inj 40mg/mlSolutionIntramuscular; IntravenousSchering Plough1966-12-312004-07-21Canada flag
Garamycin Ont 0.1%OintmentTopicalSchering Plough1966-12-312007-08-03Canada flag
Garamycin Ophthalmic Drops 0.3%Solution / dropsOphthalmicMerck Ltd.1981-12-312014-09-02Canada flag
Additional Data Available
  • Application Number
    Application Number
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    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
    Available for Purchase

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Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
GaramycinSolution / drops3 mg/1mLOphthalmicFera Pharmaceuticals2011-05-152013-06-14US flag
GaramycinOintment3 mg/1gOphthalmicFera Pharmaceuticals2010-10-082013-06-14US flag
Garamycin Gentamicin SulfateSolution3 mg/1mLOphthalmicPaddock Laboratories, Inc.2014-06-052016-04-01US flag
GentakOintment3 mg/1gOphthalmicA S Medication Solutions2006-05-08Not applicableUS flag
GentakOintment3 mg/1gOphthalmicAkorn, Inc.2013-03-11Not applicableUS flag
GentakOintment3 mg/1gOphthalmicA-S Medication Solutions2006-05-08Not applicableUS flag
GentakOintment3 mg/1gOphthalmicPreferred Pharmaceuticals, Inc.2012-10-23Not applicableUS flag
GentakOintment3 mg/1gOphthalmicProficient Rx LP2006-05-08Not applicableUS flag
GentakOintment3 mg/1gOphthalmicLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-272019-10-11US flag
GentakOintment3 mg/1gOphthalmicAkorn, Inc.2006-05-08Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number
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    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Amolg AGentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)CreamTopicalOASIS TRADING2018-11-15Not applicableUS flag
Betamycin Ophthalmic/otic SolutionGentamicin (3 mg) + Betamethasone (1 mg)SolutionAuricular (otic); OphthalmicSterimax IncNot applicableNot applicableCanada flag
Celestone-GGentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)OintmentTopicalOASIS TRADING2018-11-15Not applicableUS flag
Celestone-GGentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)OintmentTopicalOASIS TRADING2018-11-15Not applicableUS flag
Diprogen CreamGentamicin sulfate (0.1 %) + Betamethasone (0.05 %)CreamTopicalMerck Ltd.1980-12-312017-03-13Canada flag
Diprogen OintmentGentamicin (0.1 %) + Betamethasone (0.05 %)OintmentTopicalMerck Ltd.1980-12-312017-03-13Canada flag
Dom-gentamicin-betamethasoneGentamicin (3 mg) + Betamethasone (1 mg)LiquidAuricular (otic); OphthalmicDominion PharmacalNot applicableNot applicableCanada flag
Garasone Ophthalmic and Otic SolutionGentamicin (3 mg) + Betamethasone (1 mg)SolutionAuricular (otic); OphthalmicMerck Ltd.1987-12-312014-04-01Canada flag
Garasone Ophthalmic OintmentGentamicin (3 mg) + Betamethasone (1 mg)OintmentOphthalmicMerck Ltd.1983-12-312013-07-15Canada flag
Gentamicin Sulfate In 0.9% Sodium Chloride InjectionGentamicin (0.8 mg) + Sodium chloride (9 mg)SolutionIntravenousHospira Healthcare Ulc1991-12-312018-11-22Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Amolg AGentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)CreamTopicalOASIS TRADING2018-11-15Not applicableUS flag
Celestone-GGentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)OintmentTopicalOASIS TRADING2018-11-15Not applicableUS flag
Celestone-GGentamicin sulfate (1 mg/1g) + Betamethasone valerate (0.61 mg/1g)OintmentTopicalOASIS TRADING2018-11-15Not applicableUS flag


ATC Codes
S01AA11 — GentamicinS02AA14 — GentamicinD06AX07 — GentamicinS03AA06 — GentamicinJ01GB03 — Gentamicin
Drug Categories
Chemical TaxonomyProvided by Classyfire
This compound belongs to the class of organic compounds known as aminocyclitol glycosides. These are organic compounds containing an amicocyclitol moiety glycosidically linked to a carbohydrate moiety. There are two major classes of aminoglycosides containing a 2-streptamine core. They are called 4,5- and 4,6-disubstituted 2-deoxystreptamines.
Organic compounds
Super Class
Organic oxygen compounds
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Aminocyclitol glycosides
Alternative Parents
2-deoxystreptamine aminoglycosides / O-glycosyl compounds / Aminocyclitols and derivatives / Cyclohexylamines / Cyclohexanols / Oxanes / Monosaccharides / Tertiary alcohols / 1,2-aminoalcohols / Oxacyclic compounds
show 5 more
1,2-aminoalcohol / 2-deoxystreptamine aminoglycoside / Acetal / Alcohol / Aliphatic heteromonocyclic compound / Amine / Amino cyclitol glycoside / Aminocyclitol or derivatives / Cyclic alcohol / Cyclitol or derivatives
show 18 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available

Chemical Identifiers

CAS number
InChI Key


Synthesis Reference

George H. Scherr, "Preparation of gentamicin sensitized particles for agglutination tests." U.S. Patent US4100268, issued August, 1975.

General References
Not Available
Human Metabolome Database
KEGG Compound
PubChem Compound
PubChem Substance
Therapeutic Targets Database
Guide to Pharmacology
GtP Drug Page
RxList Drug Page Drug Page
PDRhealth Drug Page
AHFS Codes
  • 08:12.02 — Aminoglycosides
  • 52:04.04 — Antibacterials
  • 84:04.04 — Antibiotics
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Clinical Trials

Clinical Trials
4Active Not RecruitingTreatmentExacerbation of Ulcerative Colitis / Granulomatous Colitis / Ulcerative Colitis, Active Severe1
4CompletedNot AvailableStaphylococcus Aureus1
4CompletedPreventionBenign Prostatic Hyperplasia (BPH)1
4CompletedPreventionCalcium Nephrolithiasis / Urinary Tract Infection1
4CompletedPreventionInguinal Hernias1
4CompletedTreatmentComplicated Appendicitis1
4CompletedTreatmentDiabetic Foot Ulcers (DFU)1


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Dosage Forms
Solution / dropsAuricular (otic); Ophthalmic1 mg/ml
Solution / dropsOphthalmic0.3 %W/V
Solution / dropsAuricular (otic); Ophthalmic0.3 %W/V
CreamTopical0.05 %
OintmentTopical0.05 %
CreamTopical64 mg/100g
CreamTopical0.064 % w/w
OintmentCutaneous0.17 % w/w
Solution / dropsAuricular (otic); Ophthalmic0.3 % w/v
Cream0.05 %
CreamTopical100 mg/100g
CreamTopical3 MG/G
SolutionIntramuscular160 mg
SolutionParenteral40 mg
SolutionParenteral120 mg
SolutionIntramuscular80 mg
SolutionIntravenous20 mg
LiquidIntramuscular; Intravenous
Cream0.25 mg/g
Gel0.1 %
Ointment0.3 %
Cream0.1 %
CreamTopical0.05 g
CreamTopical0.04 g
Solution / dropsOphthalmic1 mg/ml
Cream0.05 % w/w
Ointment0.05 % w/w
CreamTopical0.5 mg/g
OintmentTopical0.5 mg/g
CreamTopical0.5 mg
LiquidAuricular (otic); Ophthalmic
Ointment100 mg/100g
Cream0.25 mg
ImplantTopical130 mg
OintmentConjunctival; Ophthalmic300 mg
SolutionParenteral160 mg
SolutionParenteral80 mg
SolutionOphthalmic3 mg/1mL
Injection, solution280 mg/2ml
SolutionAuricular (otic); Ophthalmic
Solution / dropsAuricular (otic)
Solution / dropsOphthalmic
CreamTopical1.67 mg
Injection, solutionIntramuscular; Intravenous160 mg/2ml
Injection, solutionIntramuscular; Intravenous40 mg
Injection, solutionIntramuscular; Intravenous80 mg
InjectionIntramuscular; Intravenous20 mg/2ml
InjectionIntramuscular; Intravenous40 mg/1ml
InjectionIntramuscular; Intravenous40 mg/2ml
InjectionIntramuscular; Intravenous80 mg/2ml
Solution / drops; suspension / dropsOphthalmic5 mg
OintmentOphthalmic5 mg
Solution / dropsOphthalmic1 %
SolutionIntramuscular; Intravenous160 g
InjectionIntramuscular; Intravenous120 mg
InjectionIntramuscular; Intravenous160 mg
InjectionIntramuscular; Intravenous20 mg
InjectionIntramuscular; Intravenous40 mg
InjectionIntramuscular; Intravenous80 mg
Solution / dropsOphthalmic0.3 % w/v
Solution / dropsOphthalmic1.5 g/100mL
Solution / dropsAuricular (otic)5 ml
Solution / dropsOphthalmic0.1 %
Solution / dropsOphthalmic3 mg
Cream1.5 mg
OintmentOphthalmic4.5339 mg
CreamTopical0.1 % w/w
SolutionParenteral8 g
Solution / dropsAuricular (otic); Ophthalmic0.3 %
CreamTopical15 g
CreamTopical30 g
OintmentTopical15 g
OintmentTopical30 g
OintmentOphthalmic5 g
Solution / dropsOphthalmic300 mg/100mL
Cream25 mg/100g
Injection, solution10 MG/1ML
Injection, solution120 MG/1.5ML
Injection, solution160 MG/2ML
Injection, solution40 MG/1ML
OintmentTopical0.1 %
SolutionParenteral280 mg
Solution / dropsAuricular (otic); Ophthalmic5 ml
Injection, solutionIntramuscular80 MG/2ML
Injection, solution10 MG/ML
Injection, solutionIntramuscular; Intravenous10 mg/1mL
Injection, solutionIntramuscular; Intravenous40 mg/1mL
Ointment0.1 %
SolutionOphthalmic.3 %
SolutionOphthalmic0.3 %
CreamCutaneous0.1 %
SolutionParenteral1 MG/ML
SolutionParenteral3 MG/ML
Solution / dropsOphthalmic1.4 g/100mL
SolutionIntramuscular; Intravenous
Kit5 mg
Injection, solutionParenteral40 MG/ML
Injection, solutionParenteral160 MG
Injection, solutionParenteral80 MG
SolutionIntramuscular; Intravenous80 mg/2ml
CreamTopical1 mg/1g
CreamTopical1.6639 mg
Injection, solutionIntravenous120 mg/50mL
Injection, solutionIntravenous40 mg/100mL
Injection, solutionIntravenous60 mg/100mL
Injection, solution, concentrateIntramuscular; Intravenous40 mg/1mL
Injection, solution, concentrateIntravenous10 mg/1mL
Ointment1 MG/G
Ointment1.66 mg
OintmentOphthalmic3 mg/1g
OintmentTopical1 mg/1g
PowderNot applicable1 g/1g
PowderNot applicable1 kg/1kg
SolutionOphthalmic3.0 mg/1mL
Solution / dropsOphthalmic3 mg/1mL
Injection, solutionIntravenous0.6 mg/1mL
Injection, solutionIntravenous0.8 mg/1mL
Injection, solutionIntravenous0.9 mg/1mL
Injection, solutionIntravenous1 mg/1mL
Injection, solutionIntravenous1.2 mg/1mL
Injection, solutionIntravenous1.4 mg/1mL
Injection, solutionIntravenous1.6 mg/1mL
Injection, solutionIntravenous100 mg/50mL
Injection, solutionIntravenous100 mg/100mL
Injection, solutionIntravenous60 mg/50mL
Injection, solutionIntravenous80 mg/100mL
Injection, solutionIntravenous80 mg/50mL
Solution / dropsOphthalmic0.3 %
OintmentOphthalmic0.3 %
CreamTopical0.1 g
SolutionConjunctival; Ophthalmic3 mg
SolutionParenteral126 mg
SolutionIntramuscular; Intravenous120 mg
SolutionIntramuscular120 mg
SolutionIntramuscular; Intravenous160 mg
SolutionIntramuscular; Intravenous0.16 g
SolutionIntramuscular; Intravenous; Parenteral20 mg
SolutionIntramuscular; Intravenous20 mg
SolutionIntramuscular; Intravenous40 mg
SolutionIntramuscular; Intravenous; Parenteral40 mg
InjectionParenteral80 mg
SolutionIntramuscular; Intravenous; Parenteral80 mg
CreamTopical0.1 G/100G
Injection, solution1 MG/ML
Injection, solution3 MG/ML
SolutionParenteral20 mg
SolutionIntramuscular; Intravenous80 mg
SolutionParenteral60 mg
Injection, solutionParenteral40 MG/2ML
Injection, solutionParenteral80 MG/2ML
SolutionIntravenous3 mg
SolutionIntravenous80 mg
Solution / dropsAuricular (otic); Ophthalmic1.4 g/100mL
OintmentOphthalmic3 Mg/g
Solution / dropsOphthalmic500 mg/100mL
Solution / dropsOphthalmic5 ml
CreamTopical0.065 % w/w
OintmentOphthalmic5 mg/g
Solution / dropsOphthalmic3 mg/ml
InjectionIntramuscular; Intravenous40 mg/ml
Solution / dropsOphthalmic3 %
OintmentOphthalmic7 G
Cream0.1 % W/W
Injection, solution40 MG/2ML
SolutionConjunctival; Ophthalmic0.003 g
Injection, solutionIntramuscular; Intravenous120 mg/2ml
Injection, solutionIntramuscular; Intravenous20 mg/2ml
Injection, solutionIntramuscular; Intravenous80 mg/2ml
InjectionIntramuscular; Intravenous120 mg/2ml
Solution / dropsAuricular (otic); Ophthalmic15 mg/5ml
InjectionIntramuscular; Intravenous160 mg/2ml
OintmentTopical5 gr
SolutionConjunctival; Ophthalmic214.8 mg
OintmentConjunctival; Ophthalmic0.537 g
Injection, solution80 mg/2mL
Injection, solution20 mg/2mL
CreamCutaneous0.17 % W/W
Solution / dropsOphthalmic5 mg
SuspensionConjunctival; Ophthalmic1 mg
OintmentOphthalmic3 mg
Solution / drops; suspension / dropsOphthalmic3 mg
CreamTopical1 mg
Ointment1 mg
SolutionParenteral1.6 mg
CreamTopical1.6 mg
CreamTopical0.643 mg
Solution / dropsOphthalmic; Topical
OintmentConjunctival; Ophthalmic0.3 g
CreamTopical300 mg/100g
InjectionIntramuscular; Intravenous28 0MG/2ML
CreamTopical0.3 % w/w
LiquidOphthalmic; Topical
OintmentOphthalmic; Topical
SolutionOphthalmic3 mg
Solution / dropsAuricular (otic)5 mg
CreamCutaneous0.1 %/g
Cream0.5 mg
CreamTopical1 g
Solution / dropsAuricular (otic); Ophthalmic300 mg/100mL
Suspension / dropsOphthalmic
CreamTopical0.1 %
Injection, solutionParenteral10 mg
SolutionIntramuscular; Intravenous; Subconjunctival10 mg/2ml
Injection, solutionParenteral120 mg
SolutionIntramuscular; Intravenous; Subconjunctival120 mg/2ml
CreamTopical1 mg/g
Injection, solutionParenteral40 mg
SolutionIntramuscular; Intravenous; Subconjunctival40 mg/ml
SolutionIntramuscular; Intravenous; Subconjunctival80 mg/2ml
Injection, powder, for solutionParenteral1.25 g
Solution / dropsAuricular (otic); Ophthalmic3 MG/ML
Cream1 mg/g
SolutionAuricular (otic)
BeadIntracavitary4.5 mg/1bead
Drug delivery systemTopical1.7 mg
CreamTopical50 mg/100g
Cream0.025 %
Cream0.5 mg/g
Cream1 mg
CreamTopical0.05 mg
Injection, solutionIntramuscular; Intravenous40 mg/ml
Solution / dropsOphthalmic1.6 g/100mL
Solution / dropsOphthalmic100 mg/100mL
OintmentOphthalmic; Topical0.3 g
Unit descriptionCostUnit
Gentak 0.3% Ointment 3.5 gm Tube19.99USD tube
Gentamicin Sulfate 0.1% Cream 15 gm Tube12.99USD tube
Gentamicin Sulfate 0.1% Ointment 15 gm Tube11.99USD tube
Gentamicin Sulfate 0.3% Solution 5ml Bottle11.99USD bottle
Gentamicin sulfate powder5.05USD g
Gentamicin Sulfate 10 mg/ml Solution 2ml Vial5.0USD vial
Gentamicin 40 mg/ml2.82USD ml
Gentamicin ped 10 mg/ml vial2.4USD ml
Gentak 3 mg/ml eye drops1.91USD ml
Gentamicin 3 mg/ml eye drops1.89USD ml
Gentamicin 10 mg/ml vial1.29USD ml
Garamycin 0.3 % Ointment1.2USD g
Sandoz Gentamicin Sulfate 0.3 % Ointment1.2USD g
Garamycin 0.3 % Solution0.75USD ml
Sandoz Gentamicin Sulfate 0.3 % Solution0.75USD ml
Gentamicin 40 mg/ml vial0.45USD ml
Ratio-Gentamicin Sulfate 0.1 % Cream0.43USD g
Ratio-Gentamicin Sulfate 0.1 % Ointment0.37USD g
Gentamicin 0.1% cream0.16USD g
Iso gentamicin 120 mg/100 ml0.09USD ml
Gentamicin 90 mg/ns 100 ml pb0.05USD ml
Isoton gentamicin 40 mg/100 ml0.05USD ml
Gentamicin 60 mg/ns 100 ml pb0.04USD ml
Gentamicin 100 mg/ns 100 ml0.03USD ml
Gentamicin 80 mg/ns 100 ml pb0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Not Available


Experimental Properties
melting point (°C)105 °CPhysProp
water solubility100 mg/mLNot Available
logP-3.1Not Available
Predicted Properties
Water Solubility12.6 mg/mLALOGPS
pKa (Strongest Acidic)12.55ChemAxon
pKa (Strongest Basic)10.18ChemAxon
Physiological Charge5ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area199.73 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity118.02 m3·mol-1ChemAxon
Polarizability51.92 Å3ChemAxon
Number of Rings3ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Human Intestinal Absorption-0.944
Blood Brain Barrier-0.9826
Caco-2 permeable-0.6987
P-glycoprotein substrateSubstrate0.6882
P-glycoprotein inhibitor INon-inhibitor0.6808
P-glycoprotein inhibitor IINon-inhibitor0.9586
Renal organic cation transporterNon-inhibitor0.8738
CYP450 2C9 substrateNon-substrate0.8001
CYP450 2D6 substrateNon-substrate0.8314
CYP450 3A4 substrateSubstrate0.5917
CYP450 1A2 substrateNon-inhibitor0.9034
CYP450 2C9 inhibitorNon-inhibitor0.891
CYP450 2D6 inhibitorNon-inhibitor0.9331
CYP450 2C19 inhibitorNon-inhibitor0.9043
CYP450 3A4 inhibitorNon-inhibitor0.9517
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9294
Ames testNon AMES toxic0.7338
BiodegradationNot ready biodegradable0.9588
Rat acute toxicity2.0383 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9954
hERG inhibition (predictor II)Non-inhibitor0.8784
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)


Mass Spec (NIST)
Not Available
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0i29-1319700000-e55d2931137c5abc8493
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-0904000000-de986ac47725d8f3a72a
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0592-9602000000-c7fd77457525743faeba
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-2911100000-93e47b752e7992b12263
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-2958400000-7303bf3ebe16dd1c1d60
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-2692000000-a8234ed8e0131019f62b


Escherichia coli (strain K12)
Pharmacological action
General Function
Trna binding
Specific Function
With S4 and S5 plays an important role in translational accuracy.Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Lo...
Gene Name
Uniprot ID
Uniprot Name
30S ribosomal protein S12
Molecular Weight
13736.995 Da
  1. Gill AE, Amyes SG: The contribution of a novel ribosomal S12 mutation to aminoglycoside resistance of Escherichia coli mutants. J Chemother. 2004 Aug;16(4):347-9. [PubMed:15332709]
  2. Tamehiro N, Hosaka T, Xu J, Hu H, Otake N, Ochi K: Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl Environ Microbiol. 2003 Nov;69(11):6412-7. [PubMed:14602594]
  3. Hu H, Ochi K: Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations. Appl Environ Microbiol. 2001 Apr;67(4):1885-92. [PubMed:11282646]
  4. Schroeder R, Waldsich C, Wank H: Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 2000 Jan 4;19(1):1-9. [PubMed:10619838]
Enteric bacteria and other eubacteria
Pharmacological action
In prokaryotes, the 16S rRNA is essential for recognizing the 5' end of mRNA and hence positioning it correctly on the ribosome. The 16S rRNA has a characteristic secondary structure in which half of the nucleotides are base-paired. The 16S rRNA sequence has been highly conserved and is often used for evolutionary and species comparative analysis.
  1. Doi Y, de Oliveira Garcia D, Adams J, Paterson DL: Coproduction of novel 16S rRNA methylase RmtD and metallo-beta-lactamase SPM-1 in a panresistant Pseudomonas aeruginosa isolate from Brazil. Antimicrob Agents Chemother. 2007 Mar;51(3):852-6. Epub 2006 Dec 11. [PubMed:17158944]
  2. Bogaerts P, Galimand M, Bauraing C, Deplano A, Vanhoof R, De Mendonca R, Rodriguez-Villalobos H, Struelens M, Glupczynski Y: Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium. J Antimicrob Chemother. 2007 Mar;59(3):459-64. Epub 2007 Jan 15. [PubMed:17224412]
  3. Aslangul E, Massias L, Meulemans A, Chau F, Andremont A, Courvalin P, Fantin B, Ruimy R: Acquired gentamicin resistance by permeability impairment in Enterococcus faecalis. Antimicrob Agents Chemother. 2006 Nov;50(11):3615-21. [PubMed:17065620]
  4. Schroeder R, Waldsich C, Wank H: Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 2000 Jan 4;19(1):1-9. [PubMed:10619838]
Pharmacological action
General Function
Calcium ion binding
Specific Function
Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
Gene Name
Uniprot ID
Uniprot Name
Low-density lipoprotein receptor-related protein 2
Molecular Weight
521952.77 Da
  1. Watanabe A, Nagai J, Adachi Y, Katsube T, Kitahara Y, Murakami T, Takano M: Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists. J Control Release. 2004 Mar 24;95(3):423-33. [PubMed:15023454]
  2. Takamoto K, Kawada M, Ikeda D, Yoshida M: Apolipoprotein E3 (apoE3) safeguards pig proximal tubular LLC-PK1 cells against reduction in SGLT1 activity induced by gentamicin C. Biochim Biophys Acta. 2005 Apr 15;1722(3):247-53. [PubMed:15777622]
  3. Nagai J, Saito M, Adachi Y, Yumoto R, Takano M: Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides. J Control Release. 2006 May 1;112(1):43-50. Epub 2006 Feb 20. [PubMed:16488503]
Bacillus subtilis (strain 168)
Pharmacological action
General Function
Nad+ synthase activity
Specific Function
Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction.
Gene Name
Uniprot ID
Uniprot Name
NH(3)-dependent NAD(+) synthetase
Molecular Weight
30394.995 Da
  1. Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ: Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem. 2003 Jul 17;46(15):3371-81. [PubMed:12852767]
Pharmacological action
General Function
Nadph binding
Specific Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA pre...
Gene Name
Uniprot ID
Uniprot Name
Dihydrofolate reductase
Molecular Weight
21452.61 Da
  1. Al-Omary FA, Abou-Zeid LA, Nagi MN, Habib el-SE, Abdel-Aziz AA, El-Azab AS, Abdel-Hamide SG, Al-Omar MA, Al-Obaid AM, El-Subbagh HI: Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. doi: 10.1016/j.bmc.2010.03.019. Epub 2010 Mar 12. [PubMed:20350811]


Pharmacological action
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one ...
Gene Name
Uniprot ID
Uniprot Name
Solute carrier family 22 member 6
Molecular Weight
61815.78 Da
  1. Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. [PubMed:10411577]

Drug created on June 13, 2005 07:24 / Updated on January 16, 2021 12:52

Ddi 5