Inositol-trisphosphate 3-kinase A

BE0001627ProteinHumansITPKA

Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. It is acted on by 3 drugs in DrugBank.

Gene name
ITPKA
UniProtKB entry
P23677Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
461 residues · 51,008 Da
Also known as
2.7.1.127 · Inositol 1,4,5-trisphosphate 3-kinase A · InsP 3-kinase A · IP3 3-kinase A · IP3K A

Resolves to

Protein
UniProtP23677UniProt nameIP3KA_HUMAN
Gene
HGNCHGNC:6178NCBI Gene3706GenBank32105GeneCardsITPKA
Pharmacology
IUPHAR/GtoPdb1447KEGGhsa:3706
Structure
PDB1W2CPDB1W2DPDB1W2F
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Inositol-trisphosphate 3-kinase A, and which indications are they being tested in?

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