1D-myo-inositol 1,4,5-trisphosphate

DB03401ExperimentalSmall molecule

Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the... Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum.

Mechanism: Pharmacologically active on Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Curator reviewed
Formula / weight: C₆H₁₅O₁₅P₃ · 420.0956 g/mol (avg)
Also known as: InsP3

Resolves to

Compound

UNIIMU34XVK5NRCAS85166-31-0ChEMBLCHEMBL279107ChEBI16595PubChem439456KEGGC01245

Structure

InChIKeyMMWCIQZXVOZEGG-XJTPDSDZSA-NSMILESO[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O

Targets

Q14643ITPR1Q14573ITPR3Q14571ITPR2Q99418CYTH2Q9Y6I3EPN1P51178PLCD1P35241RDXQ01082SPTBN1+1 more

What you can answer from here — as of September 23, 2026

9Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

17+ReferencesStructured and connected to the statements they support

Which drugs share a target with 1D-myo-inositol 1,4,5-trisphosphate, and which of those have an active Phase 3 trial?

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