Suppressor of tumorigenicity 14 protein

BE0001656ProteinHumansST14

Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). It is acted on by 3 drugs in DrugBank.

Gene name
ST14
UniProtKB entry
Q9Y5Y6Swiss-Prot
Cellular location
Membrane
Residues / weight
855 residues · 94,769 Da
Also known as
3.4.21.109 · Matriptase · Membrane-type serine protease 1 · MT-SP1 · Prostamin

Resolves to

Protein
UniProtQ9Y5Y6UniProt nameST14_HUMAN
Gene
HGNCHGNC:11344NCBI Gene6768GenBank6647302GeneCardsST14
Pharmacology
IUPHAR/GtoPdb2418KEGGhsa:6768
Structure
PDB1EAWPDB1EAXPDB2GV6
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Suppressor of tumorigenicity 14 protein, how selective are they, and which programs against it are still in active trials?

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