Complement factor B

BE0001701ProteinHumansCFB

Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that... It is acted on by 6 drugs in DrugBank.

Gene name
CFB
UniProtKB entry
P00751Swiss-Prot
Cellular location
Secreted
Residues / weight
764 residues · 85,532 Da
Also known as
3.4.21.47 · BF · BFD · C3/C5 convertase · GBG

Resolves to

Protein
UniProtP00751UniProt nameCFAB_HUMAN
Gene
HGNCHGNC:1037NCBI Gene629GenBank297569GeneCardsCFB
Pharmacology
IUPHAR/GtoPdb2339KEGGhsa:629
Structure
PDB1DLEPDB1Q0PPDB1RRK
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement factor B, how selective are they, and which programs against it are still in active trials?

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