This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Iptacopan
DrugBank Accession Number
DB16200
Background

Iptacopan is under investigation in clinical trial NCT04578834 (Study of Efficacy and Safety of LNP023 in Primary Iga Nephropathy Patients).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 422.525
Monoisotopic: 422.220557454
Chemical Formula
C25H30N2O4
Synonyms
  • Iptacopan
External IDs
  • LNP-023
  • LNP023

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
8E05T07Z6W
CAS number
1644670-37-0
InChI Key
RENRQMCACQEWFC-UGKGYDQZSA-N
InChI
InChI=1S/C25H30N2O4/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t19-,22-/m0/s1
IUPAC Name
4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid
SMILES
CCO[C@H]1CCN(CC2=C(OC)C=C(C)C3=C2C=CN3)[C@@H](C1)C1=CC=C(C=C1)C(O)=O

References

General References
Not Available
ChemSpider
75533872
ZINC
ZINC000223246892
PDBe Ligand
JGQ
PDB Entries
6rav

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentParoxysmal Nocturnal Haemoglobinuria (PNH)2
3Not Yet RecruitingTreatmentParoxysmal Nocturnal Haemoglobinuria (PNH)1
3RecruitingTreatmentAtypical Hemolytic Uremic Syndrome (aHUS)1
3RecruitingTreatmentC3G1
3RecruitingTreatmentIgA Nephropathy (IgAN)1
3RecruitingTreatmentParoxysmal Nocturnal Haemoglobinuria (PNH)1
3RecruitingTreatmentPrimary IgA Nephropathy1
2Active Not RecruitingTreatmentGlomerulonephritis, Membranous1
2CompletedTreatmentGlomerulonephritis1
2CompletedTreatmentIgA Nephropathy (IgAN)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00578 mg/mLALOGPS
logP4.08ALOGPS
logP1.4Chemaxon
logS-4.9ALOGPS
pKa (Strongest Acidic)3.7Chemaxon
pKa (Strongest Basic)8.75Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area74.79 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity121.95 m3·mol-1Chemaxon
Polarizability47.52 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 15, 2020 18:15 / Updated at February 21, 2021 18:55