Flavohemoprotein

BE0001704ProteinCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)hmp

Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. It is acted on by 2 drugs in DrugBank.

Gene name
hmp
UniProtKB entry
P39662Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
403 residues · 44,782 Da
Also known as
fhp · Flavohemoglobin · Hemoglobin-like protein · Nitric oxide dioxygenase · NO oxygenase

Resolves to

Protein
UniProtP39662UniProt nameHMP_CUPNH
Gene
NCBI Gene2656642GenBank460999
Pharmacology
KEGGreh:PHG200
Structure
PDB1CQXPDB3OZUPDB3OZV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Flavohemoprotein, how selective are they, and which programs against it are still in active trials?

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