Bifunctional (p)ppGpp synthase/hydrolase RelA

BE0001706ProteinStreptococcus dysgalactiae subsp. equisimilisrelA

In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. It is acted on by 2 drugs in DrugBank.

Gene name
relA
UniProtKB entry
Q54089Swiss-Prot
Residues / weight
739 residues · 83,913 Da
Also known as
rel

Resolves to

Protein
UniProtQ54089UniProt nameRELA_STREQ
Gene
GenBank407881
Structure
PDB1VJ7
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bifunctional (p)ppGpp synthase/hydrolase RelA, and which indications are they being tested in?

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