Carminomycin 4-O-methyltransferase DnrK

BE0001712ProteinStreptomyces peucetiusdnrK

Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. It is acted on by 2 drugs in DrugBank.

Gene name
dnrK
UniProtKB entry
Q06528Swiss-Prot
Residues / weight
356 residues · 38,782 Da
Also known as
2.1.1.292 · Anthracycline 4-O-methyltransferase · COMT

Resolves to

Protein
UniProtQ06528UniProt nameDNRK_STRPE
Gene
GenBank295169
Pharmacology
KEGGag:AAA26712
Structure
PDB1TW2PDB1TW3PDB4WXH
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Carminomycin 4-O-methyltransferase DnrK, and which indications are they being tested in?

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