Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III

BE0001723ProteinMycobacterium tuberculosisfabH

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. It is acted on by 7 drugs in DrugBank.

Gene name
fabH
UniProtKB entry
P9WNG3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
335 residues · 34,872 Da
Also known as
2.3.1.180 · 2.3.1.301 · 3-oxoacyl-[acyl-carrier-protein] synthase 3 · 3-oxoacyl-[acyl-carrier-protein] synthase III · Beta-ketoacyl-ACP synthase III

Resolves to

Protein
UniProtP9WNG3UniProt nameFABH_MYCTU
Gene
NCBI Gene887381
Pharmacology
KEGGmtu:Rv0533c
Structure
PDB1HZPPDB1M1MPDB1U6E
Drugs

What you can answer from here — as of May 03, 2025

7DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III, how selective are they, and which programs against it are still in active trials?

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