Beta-lactamase OXA-1
Details
- Name
- Beta-lactamase OXA-1
- Kind
- protein
- Synonyms
- 3.5.2.6
- oxa1
- Penicillinase
- Gene Name
- bla
- UniProtKB Entry
- P13661Swiss-Prot
- Organism
- Escherichia coli
- NCBI Taxonomy ID
- 562
- Amino acid sequence
>lcl|BSEQ0022475|Beta-lactamase OXA-1 MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNK AKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVV WVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLR KIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSG HKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL
- Number of residues
- 276
- Molecular Weight
- 30879.895
- Theoretical pI
- 8.62
- GO Classification
- Functionsbeta-lactamase activity / penicillin bindingProcessesantibiotic catabolic process / response to antibiotic
- General Function
- This is an oxacillin-hydrolyzing beta-lactamase.
- Specific Function
- beta-lactamase activity
- Pfam Domain Function
- Transpeptidase (PF00905)
- Signal Regions
- 1-25
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003435|831 bp ATGAAAAACACAATACATATCAACTTCGCTATTTTTTTAATAATTGCAAATATTATCTAC AGCAGCGCCAGTGCATCAACAGATATCTCTACTGTTGCATCTCCATTATTTGAAGGAACT GAAGGTTGTTTTTTACTTTACGATGCATCCACAAACGCTGAAATTGCTCAATTCAATAAA GCAAAGTGTGCAACGCAAATGGCACCAGATTCAACTTTCAAGATCGCATTATCACTTATG GCATTTGATGCGGAAATAATAGATCAGAAAACCATATTCAAATGGGATAAAACCCCCAAA GGAATGGAGATCTGGAACAGCAATCATACACCAAAGACGTGGATGCAATTTTCTGTTGTT TGGGTTTCGCAAGAAATAACCCAAAAAATTAGATTAAATAAAATCAAGAATTATCTCAAA GATTTTGATTATGGAAATCAAGACTTCTCTGGAGATAAAGAAAGAAACAACGGATTAACA GAAGCATGGCTCGAAAGTAGCTTAAAAATTTCACCAGAAGAACAAATTCAATTCCTGCGT AAAATTATTAATCACAATCTCCCAGTTAAAAACTCAGCCATAGAAAACACCATAGAGAAC ATGTATCTACAAGATCTGGATAATAGTACAAAACTGTATGGGAAAACTGGTGCAGGATTC ACAGCAAATAGAACCTTACAAAACGGATGGTTTGAAGGGTTTATTATAAGCAAATCAGGA CATAAATATGTTTTTGTGTCCGCACTTACAGGAAACTTGGGGTCGAATTTAACATCAAGC ATAAAAGCCAAGAAAAATGCGATCACCATTCTAAACACACTAAATTTATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P13661 UniProtKB Entry Name BLO1_ECOLX GenBank Protein ID 152064 GenBank Gene ID J02967 PDB ID(s) 1M6K, 3ISG, 4MLL KEGG ID ag:AAA91586 NCBI Gene ID 13906817 - General References
- Ouellette M, Bissonnette L, Roy PH: Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7378-82. [Article]
- Sun T, Nukaga M, Mayama K, Braswell EH, Knox JR: Comparison of beta-lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase. Protein Sci. 2003 Jan;12(1):82-91. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Lysine Nz-Carboxylic Acid experimental unknown target Details