Serine protease 1

BE0001739ProteinHumansPRSS1

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. It is acted on by 107 drugs in DrugBank.

Gene name
PRSS1
UniProtKB entry
P07477Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
247 residues · 26,558 Da
Also known as
3.4.21.4 · Anionic trypsin I · Anionic trypsin-I · Beta-trypsin · Cationic trypsinogen

Resolves to

Protein
UniProtP07477UniProt nameTRY1_HUMAN
Gene
HGNCHGNC:9475NCBI Gene5644GenBank521216GeneCardsPRSS1
Pharmacology
IUPHAR/GtoPdb2397KEGGhsa:5644
Structure
PDB1FXYPDB1TRNPDB2RA3
Drugs

What you can answer from here — as of September 03, 2024

107DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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192+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine protease 1, how selective are they, and which programs against it are still in active trials?

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