Formate acetyltransferase 1

BE0001741ProteinEscherichia coli (strain K12)pflB

Catalyzes the conversion of pyruvate to formate and acetyl-CoA (PubMed:4615902). It is acted on by 3 drugs in DrugBank.

Gene name
pflB
UniProtKB entry
P09373Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
760 residues · 85,357 Da
Also known as
2.3.1.54 · pfl · Pyruvate formate-lyase 1

Resolves to

Protein
UniProtP09373UniProt namePFLB_ECOLI
Gene
NCBI Gene945514GenBank42370
Pharmacology
KEGGecj:JW0886
Structure
PDB1CM5PDB1H16PDB1H17
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Formate acetyltransferase 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In