Shiga-like toxin 1 subunit B

BE0001772ProteinBacteriophage H30stxB

The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli. It is acted on by 6 drugs in DrugBank.

Gene name
stxB
UniProtKB entry
P69178Swiss-Prot
Cellular location
Secreted
Residues / weight
89 residues · 9,743 Da
Also known as
SLT-1 B subunit · Verocytotoxin 1 subunit B · Verotoxin 1 subunit B

Resolves to

Protein
UniProtP69178UniProt nameSTXB_BPH30
Gene
GenBank736314
Structure
PDB1D1KPDB2C5C
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Shiga-like toxin 1 subunit B, and which indications are they being tested in?

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