Shiga-like toxin 1 subunit B
Details
- Name
- Shiga-like toxin 1 subunit B
- Kind
- protein
- Synonyms
- SLT-1 B subunit
- Verocytotoxin 1 subunit B
- Verotoxin 1 subunit B
- Gene Name
- stxB
- UniProtKB Entry
- P69178Swiss-Prot
- Organism
- Bacteriophage H30
- NCBI Taxonomy ID
- 12371
- Amino acid sequence
>lcl|BSEQ0011267|Shiga-like toxin 1 subunit B MKKTLLIAASLSFFSASALATPDCVTGKVEYTKYNDDDTFTVKVGDKELFTNRWNLQSLL LSAQITGMTVTIKTNACHNGGGFSEVIFR
- Number of residues
- 89
- Molecular Weight
- 9743.07
- Theoretical pI
- 8.22
- GO Classification
- Processeshemolysis by symbiont of host erythrocytes / pathogenesisComponentsextracellular region
- General Function
- Not Available
- Specific Function
- The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
- Pfam Domain Function
- SLT_beta (PF02258)
- Signal Regions
- 1-20
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0003513|211 bp ATGAAAAAAACATTATTAATAGCTGCATCGCTTTCATTTTTTTCAGCAAGTGCGCTGGCG ACGCCTGATTGTGTAACTGGAAAGGTGGAGTATACAAAATATAATGATGACGATACCTTT ACAGTTAAAGTGGGTGATAAAGAATTATTTACCAACAGATGGAATCTTCAGTCTCTTCTT CTCAGTGCGCAAATTACGGGGATGACTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P69178 UniProtKB Entry Name STXB_BPH30 GenBank Protein ID 736314 GenBank Gene ID X07903 PDB ID(s) 1D1K, 2C5C - General References
- Kozlov YuV, Kabishev AA, Lukyanov EV, Bayev AA: The primary structure of the operons coding for Shigella dysenteriae toxin and temperature phage H30 shiga-like toxin. Gene. 1988 Jul 30;67(2):213-21. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Ethyl N-methylcarbamate experimental unknown target Details Ethyl-Carbamic Acid Methyl Ester experimental unknown target Details Beta-D-Glucose experimental unknown target Details DIETHYL PROPANE-1,3-DIYLBISCARBAMATE experimental unknown target Details