Shiga-like toxin 1 subunit B

Details

Name
Shiga-like toxin 1 subunit B
Kind
protein
Synonyms
  • SLT-1 B subunit
  • Verocytotoxin 1 subunit B
  • Verotoxin 1 subunit B
Gene Name
stxB
UniProtKB Entry
P69178Swiss-Prot
Organism
Bacteriophage H30
NCBI Taxonomy ID
12371
Amino acid sequence
>lcl|BSEQ0011267|Shiga-like toxin 1 subunit B
MKKTLLIAASLSFFSASALATPDCVTGKVEYTKYNDDDTFTVKVGDKELFTNRWNLQSLL
LSAQITGMTVTIKTNACHNGGGFSEVIFR
Number of residues
89
Molecular Weight
9743.07
Theoretical pI
8.22
GO Classification
Processes
hemolysis by symbiont of host erythrocytes / pathogenesis
Components
extracellular region
General Function
Not Available
Specific Function
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
Pfam Domain Function
Signal Regions
1-20
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0003513|211 bp
ATGAAAAAAACATTATTAATAGCTGCATCGCTTTCATTTTTTTCAGCAAGTGCGCTGGCG
ACGCCTGATTGTGTAACTGGAAAGGTGGAGTATACAAAATATAATGATGACGATACCTTT
ACAGTTAAAGTGGGTGATAAAGAATTATTTACCAACAGATGGAATCTTCAGTCTCTTCTT
CTCAGTGCGCAAATTACGGGGATGACTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP69178
UniProtKB Entry NameSTXB_BPH30
GenBank Protein ID736314
GenBank Gene IDX07903
PDB ID(s)1D1K, 2C5C
General References
  1. Kozlov YuV, Kabishev AA, Lukyanov EV, Bayev AA: The primary structure of the operons coding for Shigella dysenteriae toxin and temperature phage H30 shiga-like toxin. Gene. 1988 Jul 30;67(2):213-21. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Ethyl N-methylcarbamateexperimentalunknowntargetDetails
Ethyl-Carbamic Acid Methyl EsterexperimentalunknowntargetDetails
Beta-D-GlucoseexperimentalunknowntargetDetails
DIETHYL PROPANE-1,3-DIYLBISCARBAMATEexperimentalunknowntargetDetails