Death-associated protein kinase 1

BE0001776ProteinHumansDAPK1

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. It is acted on by 4 drugs in DrugBank.

Gene name
DAPK1
UniProtKB entry
P53355Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,430 residues · 160,045 Da
Also known as
2.7.11.1 · DAP kinase 1 · DAPK

Resolves to

Protein
UniProtP53355UniProt nameDAPK1_HUMAN
Gene
HGNCHGNC:2674NCBI Gene1612GenBank2094873GeneCardsDAPK1
Pharmacology
IUPHAR/GtoPdb2002KEGGhsa:1612
Structure
PDB1IG1PDB1JKKPDB1JKL
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Death-associated protein kinase 1, how selective are they, and which programs against it are still in active trials?

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