Methylmalonyl-CoA carboxyltransferase 12S subunit

BE0001780ProteinPropionibacterium freudenreichii subsp. shermanii

The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin. It is acted on by 2 drugs in DrugBank.

UniProtKB entry
Q8GBW6Swiss-Prot
Residues / weight
611 residues · 65,926 Da
Also known as
2.1.3.1 · Transcarboxylase 12S subunit

Resolves to

Protein
UniProtQ8GBW6UniProt name12S_PROFR
Gene
GenBank150933
Structure
PDB1ON3PDB1ON9
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Methylmalonyl-CoA carboxyltransferase 12S subunit, and which indications are they being tested in?

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