2-oxopropyl-CoM reductase, carboxylating

BE0001784ProteinXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)xecC

Involved in aliphatic epoxide carboxylation (PubMed:10411892, PubMed:9150202). It is acted on by 2 drugs in DrugBank.

Gene name
xecC
UniProtKB entry
Q56839Swiss-Prot
Residues / weight
523 residues · 57,347 Da
Also known as
1.8.1.5 · 2-ketopropyl-coenzyme M oxidoreductase/carboxylase · 2-KPCC · Aliphatic epoxide carboxylation component II · Epoxide carboxylase component II

Resolves to

Protein
UniProtQ56839UniProt nameXECC_XANVE
Gene
GenBank929914
Pharmacology
KEGGxau:Xaut_4867
Structure
PDB1MO9PDB1MOKPDB2C3C
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2-oxopropyl-CoM reductase, carboxylating, how selective are they, and which programs against it are still in active trials?

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