Dual specificity protein kinase CLK1

BE0001824ProteinHumansCLK1

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. It is acted on by 6 drugs in DrugBank.

Gene name
CLK1
UniProtKB entry
P49759Swiss-Prot
Cellular location
Nucleus
Residues / weight
484 residues · 57,290 Da
Also known as
2.7.12.1 · CDC-like kinase 1 · CLK

Resolves to

Protein
UniProtP49759UniProt nameCLK1_HUMAN
Gene
HGNCHGNC:2068NCBI Gene1195GenBank632964GeneCardsCLK1
Pharmacology
IUPHAR/GtoPdb1990KEGGhsa:1195
Structure
PDB1Z57PDB2VAGPDB5J1V
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity protein kinase CLK1, how selective are they, and which programs against it are still in active trials?

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