Kinesin-like protein KIF11

BE0001852ProteinHumansKIF11

Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). It is acted on by 16 drugs in DrugBank.

Gene name
KIF11
UniProtKB entry
P52732Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,056 residues · 119,158 Da
Also known as
EG5 · Kinesin-like protein 1 · Kinesin-like spindle protein HKSP · Kinesin-related motor protein Eg5 · KNSL1

Resolves to

Protein
UniProtP52732UniProt nameKIF11_HUMAN
Gene
HGNCHGNC:6388NCBI Gene3832GenBank1155084GeneCardsKIF11
Pharmacology
IUPHAR/GtoPdb2788KEGGhsa:3832
Structure
PDB1II6PDB1Q0BPDB1X88
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Kinesin-like protein KIF11, and which indications are they being tested in?

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