MK-0731

DB08037InvestigationalSmall molecule

MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent.

Mechanism: Pharmacologically active on Kinesin-like protein KIF11
Curator reviewed
Formula / weight: C₂₅H₂₈F₃N₃O₂ · 459.5039 g/mol (avg)
Code names: MK-0731

Resolves to

Compound

Structure

InChIKeyMYBGWENAVMIGMM-GIFXNVAJSA-NSMILESCN([C@H]1CCN(C)C[C@H]1F)C(=O)N1CC(=C[C@@]1(CO)C1=CC=CC=C1)C1=C(F)C=CC(F)=C1

Targets

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with MK-0731, and which of those have an active Phase 3 trial?

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