TGF-beta receptor type-2

BE0001861ProteinHumansTGFBR2

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. It is acted on by 5 drugs in DrugBank.

Gene name
TGFBR2
UniProtKB entry
P37173Swiss-Prot
Cellular location
Cell membrane
Residues / weight
567 residues · 64,567 Da
Also known as
2.7.11.30 · TbetaR-II · TGF-beta receptor type II · TGF-beta type II receptor · TGFR-2

Resolves to

Protein
UniProtP37173UniProt nameTGFR2_HUMAN
Gene
HGNCHGNC:11773NCBI Gene7048GenBank339570GeneCardsTGFBR2
Pharmacology
IUPHAR/GtoPdb1795KEGGhsa:7048
Structure
PDB1KTZPDB1M9ZPDB1PLO
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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39GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on TGF-beta receptor type-2, how selective are they, and which programs against it are still in active trials?

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