D-2-hydroxyacid dehydrogenase (NAD+)

BE0001866ProteinLactobacillus paracasei

Catalyzes the NAD dependent reversible, stereospecific interconversion between 2-ketocarboxylic acids and D-2-hydroxy-carboxylic acids. It is acted on by 1 drug in DrugBank.

UniProtKB entry
P17584Swiss-Prot
Residues / weight
333 residues · 36,893 Da
Also known as
1.1.1.- · 1.1.1.345 · D-2-hydroxyisocaproate dehydrogenase · D-HICDH

Resolves to

Protein
UniProtP17584UniProt nameDHD2_LACPA
Gene
GenBank149538
Structure
PDB1DXY
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on D-2-hydroxyacid dehydrogenase (NAD+), and which indications are they being tested in?

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