Thromboxane-A synthase

BE0001893ProteinHumansTBXAS1

Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, PubMed:24009185, PubMed:8436233, PubMed:9873013). It is acted on by 15 drugs in DrugBank.

Gene name
TBXAS1
UniProtKB entry
P24557Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
533 residues · 60,518 Da
Also known as
5.3.99.5 · CYP5 · CYP5A1 · Cytochrome P450 5A1 · Hydroperoxy icosatetraenoate dehydratase

Resolves to

Protein
UniProtP24557UniProt nameTHAS_HUMAN
Gene
HGNCHGNC:11609NCBI Gene6916GenBank338704GeneCardsTBXAS1
Pharmacology
IUPHAR/GtoPdb1353KEGGhsa:6916
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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61+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Thromboxane-A synthase, and which indications are they being tested in?

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