GDP-L-fucose synthase

BE0001903ProteinEscherichia coli (strain K12)fcl

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. It is acted on by 3 drugs in DrugBank.

Gene name
fcl
UniProtKB entry
P32055Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
321 residues · 36,141 Da
Also known as
1.1.1.271 · GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase · wcaG · yefB

Resolves to

Protein
UniProtP32055UniProt nameFCL_ECOLI
Gene
NCBI Gene946563GenBank1407613
Pharmacology
KEGGecj:JW2037
Structure
PDB1BSVPDB1BWSPDB1E6U
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on GDP-L-fucose synthase, and which indications are they being tested in?

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