Acetyl-coenzyme A synthetase

BE0001916ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)acs

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. It is acted on by 2 drugs in DrugBank.

Gene name
acs
UniProtKB entry
Q8ZKF6Swiss-Prot
Residues / weight
652 residues · 72,152 Da
Also known as
6.2.1.1 · AcCoA synthetase · Acetate--CoA ligase · Acyl-activating enzyme

Resolves to

Protein
UniProtQ8ZKF6UniProt nameACSA_SALTY
Gene
NCBI Gene1255801GenBank16422835
Pharmacology
KEGGstm:STM4275
Structure
PDB1PG3PDB1PG4PDB2P20
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Acetyl-coenzyme A synthetase, and which indications are they being tested in?

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