Glutaryl-CoA dehydrogenase, mitochondrial

BE0001921ProteinHumansGCDH

Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It is acted on by 2 drugs in DrugBank.

Gene name
GCDH
UniProtKB entry
Q92947Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
438 residues · 48,127 Da
Also known as
1.3.8.6 · GCD

Resolves to

Protein
UniProtQ92947UniProt nameGCDH_HUMAN
Gene
HGNCHGNC:4189NCBI Gene2639GenBank1549327GeneCardsGCDH
Pharmacology
KEGGhsa:2639
Structure
PDB1SIQPDB1SIRPDB2R0M
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutaryl-CoA dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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