Chorismate synthase

BE0001922ProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)aroC

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways... It is acted on by 3 drugs in DrugBank.

Gene name
aroC
UniProtKB entry
P0A2Y7Swiss-Prot
Residues / weight
388 residues · 42,871 Da
Also known as
4.2.3.5 · 5-enolpyruvylshikimate-3-phosphate phospholyase · CS

Resolves to

Protein
UniProtP0A2Y7UniProt nameAROC_STRR6
Gene
NCBI Gene934448GenBank15458869
Pharmacology
KEGGspr:spr1232
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Chorismate synthase, how selective are they, and which programs against it are still in active trials?

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