ADP-ribose pyrophosphatase

BE0001935ProteinHumansNUDT9

Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate (PubMed:11385575, PubMed:37343711). It is acted on by 2 drugs in DrugBank.

Gene name
NUDT9
UniProtKB entry
Q9BW91Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
350 residues · 39,125 Da
Also known as
3.6.1.13 · Adenosine diphosphoribose pyrophosphatase · ADP-ribose diphosphatase · ADP-ribose phosphohydrolase · ADPR-PPase

Resolves to

Protein
UniProtQ9BW91UniProt nameNUDT9_HUMAN
Gene
HGNCHGNC:8056NCBI Gene53343GenBank14160858GeneCardsNUDT9
Pharmacology
KEGGhsa:53343
Structure
PDB1Q33PDB1QVJ
Drugs

What you can answer from here — as of June 05, 2026

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
16+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on ADP-ribose pyrophosphatase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In