Fumarate reductase (cytochrome)

BE0002001ProteinShewanella frigidimarinafccA

Flavocytochrome that catalyzes the reduction of fumarate to succinate (PubMed:10978153). It is acted on by 4 drugs in DrugBank.

Gene name
fccA
UniProtKB entry
P0C278Swiss-Prot
Cellular location
Periplasm
Residues / weight
571 residues · 60,621 Da
Also known as
1.3.2.4 · 1.3.5.4 · fcc3 · Flavocytochrome c · Flavocytochrome c3

Resolves to

Protein
UniProtP0C278UniProt nameFCCA_SHEFR
Gene
GenBank4539587
Structure
PDB1E39PDB1JRXPDB1JRY
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fumarate reductase (cytochrome), how selective are they, and which programs against it are still in active trials?

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