Xanthine-guanine phosphoribosyltransferase

BE0002009ProteinEscherichia coli (strain K12)gpt

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and... It is acted on by 4 drugs in DrugBank.

Gene name
gpt
UniProtKB entry
P0A9M5Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
152 residues · 16,970 Da
Also known as
2.4.2.- · 2.4.2.22 · gpp · gxu · Xanthine phosphoribosyltransferase

Resolves to

Protein
UniProtP0A9M5UniProt nameXGPT_ECOLI
Gene
NCBI Gene944817GenBank41607
Pharmacology
KEGGecj:JW0228
Structure
PDB1A95PDB1A96PDB1A97
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Xanthine-guanine phosphoribosyltransferase, and which indications are they being tested in?

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