Thioesterase 1/protease 1/lysophospholipase L1

BE0002014ProteinEscherichia coli (strain K12)tesA

TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease (PubMed:10423542, PubMed:1864840, PubMed:238979, PubMed:4554913, PubMed:4945109, PubMed:791643, PubMed:8098033, PubMed:8132479, PubMed:8432696, PubMed:9070299). It is acted on by 3 drugs in DrugBank.

Gene name
tesA
UniProtKB entry
P0ADA1Swiss-Prot
Cellular location
Periplasm
Residues / weight
208 residues · 23,622 Da
Also known as
3.1.2.- · Acyl-CoA thioesterase 1 · Acyl-CoA thioesterase I · apeA · Arylesterase

Resolves to

Protein
UniProtP0ADA1UniProt nameTESA_ECOLI
Gene
NCBI Gene945127GenBank290474
Pharmacology
KEGGecj:JW0483
Structure
PDB1IVNPDB1J00PDB1JRL
Drugs

What you can answer from here — as of May 03, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
12+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Thioesterase 1/protease 1/lysophospholipase L1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In