Glycerol uptake facilitator protein

BE0002037ProteinEscherichia coli (strain K12)glpF

Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism (PubMed:11039922, PubMed:11226336, PubMed:6998951, PubMed:7512955). It is acted on by 3 drugs in DrugBank.

Gene name
glpF
UniProtKB entry
P0AER0Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
281 residues · 29,780 Da
Also known as
Aquaglyceroporin · Glycerol facilitator

Resolves to

Protein
UniProtP0AER0UniProt nameGLPF_ECOLI
Gene
NCBI Gene948422
Pharmacology
KEGGecj:JW3898
Structure
PDB1FX8PDB1LDAPDB1LDF
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycerol uptake facilitator protein, how selective are they, and which programs against it are still in active trials?

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