Glycerin

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.

Mechanism: When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.
Curator reviewed
Primary indication: It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.Curator reviewed · 30 structured indications
Formula / weight: C₃H₈O₃ · 92.0938 g/mol (avg)
First approval: Canada, 1997 · United States, 1974
Also known as: Glycerine · Glycerol · Monoctanoin component D · Propanetriol · Trihydroxypropane
Code names: E-422 · Fema no. 2525 · INS-422 · INS No.422 · M 314429 · NSC-9230 · PZN 7474853
Brand names: Clear Eyes Cooling Comfort
Clear Eyes Redness Relief Reformulated Nov 2011
Fleet Mineral Oil
Genteal Tears
Glycerolyte 57
Pedia-lax Liquid
Preparation H Cream
Procalamine 3
Refresh Optive Advanced
Tears Lubricant

What you can answer from here — as of May 03, 2025

14Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3TransportersSubstrate / inhibitor direction, not just membership

Listed above

430Drug interactionsStructured to mechanism, not free text

86Clinical trialsPhase, status and sponsor resolved per trial

30Structured indicationsCondition, population, route and combination as fields, not prose

6ContraindicationsEach with its own population and attribute set

2,449Marketed productsAcross 10 countries and 576 labellers

2ATC codesIncluding every combination product, plus 24 drug categories

20+ReferencesStructured and connected to the statements they support

Which drugs share a target with Glycerin, and which of those have an active Phase 3 trial?

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