Release factor glutamine methyltransferase

BE0002051ProteinEscherichia coli (strain K12)prmC

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, i.e. on 'Gln-235' in RF1 and on 'Gln-252' in RF2. It is acted on by 1 drug in DrugBank.

Gene name
prmC
UniProtKB entry
P0ACC1Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
277 residues · 30,975 Da
Also known as
2.1.1.297 · hemK · M.EcoKHemKP · N5-glutamine methyltransferase PrmC · Protein release factor methylation C

Resolves to

Protein
UniProtP0ACC1UniProt namePRMC_ECOLI
Gene
NCBI Gene945779
Pharmacology
KEGGecj:JW1203
Structure
PDB1T43PDB2B3T
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Release factor glutamine methyltransferase, and which indications are they being tested in?

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