5,10-methylenetetrahydrofolate reductase

BE0002064ProteinEscherichia coli (strain K12)metF

Catalyzes the NADH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (PubMed:9922232). It is acted on by 1 drug in DrugBank.

Gene name
metF
UniProtKB entry
P0AEZ1Swiss-Prot
Residues / weight
296 residues · 33,102 Da
Also known as
1.5.1.20 · 1.5.1.54 · MTHFR · NADH-dependent 5,10-methylenetetrahydrofolate reductase

Resolves to

Protein
UniProtP0AEZ1UniProt nameMETF_ECOLI
Gene
NCBI Gene948432
Pharmacology
KEGGecj:JW3913
Structure
PDB1B5TPDB1ZP3PDB1ZP4
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5,10-methylenetetrahydrofolate reductase, how selective are they, and which programs against it are still in active trials?

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