cGMP-dependent 3',5'-cyclic phosphodiesterase

BE0002085ProteinHumansPDE2A

cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). It is acted on by 8 drugs in DrugBank.

Gene name
PDE2A
UniProtKB entry
O00408Swiss-Prot
Cellular location
Cell membrane
Residues / weight
941 residues · 105,716 Da
Also known as
3.1.4.17 · CGS-PDE · cGSPDE · Cyclic GMP-stimulated phosphodiesterase

Resolves to

Protein
UniProtO00408UniProt namePDE2A_HUMAN
Gene
HGNCHGNC:8777NCBI Gene5138GenBank2108052GeneCardsPDE2A
Pharmacology
IUPHAR/GtoPdb1297KEGGhsa:5138
Structure
PDB1Z1LPDB3IBJPDB3ITM
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which compounds in development act on cGMP-dependent 3',5'-cyclic phosphodiesterase, and which indications are they being tested in?

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