Inactive dihydropteroate synthase 2

BE0002087ProteinMycobacterium leprae (strain TN)folP2

Has very low affinity for the DHPS substrate 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. It is acted on by 1 drug in DrugBank.

Gene name
folP2
UniProtKB entry
P0C0X2Swiss-Prot
Residues / weight
291 residues · 30,851 Da
Also known as
DHPS 2 · Dihydropteroate pyrophosphorylase 2

Resolves to

Protein
UniProtP0C0X2UniProt nameDHPS2_MYCLE
Gene
NCBI Gene910150GenBank699152
Pharmacology
KEGGmle:ML1063
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inactive dihydropteroate synthase 2, how selective are they, and which programs against it are still in active trials?

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