Multiple coagulation factor deficiency protein 2

BE0002120ProteinHumansMCFD2

The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. It is acted on by 3 drugs in DrugBank.

Gene name
MCFD2
UniProtKB entry
Q8NI22Swiss-Prot
Cellular location
Endoplasmic reticulum-Golgi intermediate compartment
Residues / weight
146 residues · 16,390 Da
Also known as
Neural stem cell-derived neuronal survival protein · SDNSF

Resolves to

Protein
UniProtQ8NI22UniProt nameMCFD2_HUMAN
Gene
HGNCHGNC:18451NCBI Gene90411GenBank20799383GeneCardsMCFD2
Pharmacology
KEGGhsa:90411
Structure
PDB2VRGPDB3A4UPDB3LCP
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multiple coagulation factor deficiency protein 2, how selective are they, and which programs against it are still in active trials?

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