Serine protease hepsin

BE0002128ProteinHumansHPN

Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, PubMed:21875933). It is acted on by 4 drugs in DrugBank.

Gene name
HPN
UniProtKB entry
P05981Swiss-Prot
Cellular location
Cell membrane
Residues / weight
417 residues · 45,011 Da
Also known as
3.4.21.106 · TMPRSS1 · Transmembrane protease serine 1

Resolves to

Protein
UniProtP05981UniProt nameHEPS_HUMAN
Gene
HGNCHGNC:5155NCBI Gene3249GenBank306886GeneCardsHPN
Pharmacology
KEGGhsa:3249
Structure
PDB1O5EPDB1O5FPDB1P57
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
26GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Serine protease hepsin, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In