Procathepsin L

BE0002135ProteinHumansCTSL

Thiol protease important for the overall degradation of proteins in lysosomes (Probable). It is acted on by 7 drugs in DrugBank.

Gene name
CTSL
UniProtKB entry
P07711Swiss-Prot
Cellular location
Lysosome
Residues / weight
333 residues · 37,564 Da
Also known as
3.4.22.15 · Cathepsin L1 · CTSL1 · Major excreted protein · MEP

Resolves to

Protein
UniProtP07711UniProt nameCATL1_HUMAN
Gene
HGNCHGNC:2537NCBI Gene1514GenBank29715GeneCardsCTSL
Pharmacology
IUPHAR/GtoPdb2351KEGGhsa:1514
Structure
PDB1CJLPDB1CS8PDB1ICF
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Procathepsin L, how selective are they, and which programs against it are still in active trials?

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