Vesicle-associated membrane protein 1
Details
- Name
- Vesicle-associated membrane protein 1
- Kind
- protein
- Synonyms
- SYB1
- Synaptobrevin-1
- VAMP-1
- Gene Name
- VAMP1
- UniProtKB Entry
- P23763Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004190|Vesicle-associated membrane protein 1 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQ KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT
- Number of residues
- 118
- Molecular Weight
- 12901.815
- Theoretical pI
- 6.59
- GO Classification
- Functionssyntaxin bindingComponentsneuron projection / plasma membrane
- General Function
- Involved in the targeting and/or fusion of transport vesicles to their target membrane
- Specific Function
- SNAP receptor activity
- Pfam Domain Function
- Synaptobrevin (PF00957)
- Signal Regions
- Not Available
- Transmembrane Regions
- 97-116
- Cellular Location
- Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
- Gene sequence
>lcl|BSEQ0016691|Vesicle-associated membrane protein 1 (VAMP1) ATGTCTGCTCCAGCTCAGCCACCTGCTGAAGGGACAGAAGGGACTGCCCCAGGTGGGGGT CCCCCTGGCCCTCCTCCTAACATGACCAGTAACAGACGACTACAGCAAACCCAGGCACAA GTGGAGGAGGTGGTGGACATCATACGTGTGAACGTGGACAAGGTCCTGGAGAGGGACCAG AAGCTGTCAGAGCTGGATGACCGAGCTGATGCCTTGCAGGCAGGAGCATCACAATTTGAG AGCAGTGCTGCCAAGCTAAAGAGGAAGTATTGGTGGAAAAACTGCAAGATGATGATCATG CTGGGAGCCATCTGTGCCATCATCGTGGTAGTTATTGTAAGAAGAGGCTGA
- Chromosome Location
- 12
- Locus
- 12p13.31
- External Identifiers
Resource Link UniProtKB ID P23763 UniProtKB Entry Name VAMP1_HUMAN GenBank Protein ID 338625 GenBank Gene ID M36200 GeneCard ID VAMP1 GenAtlas ID VAMP1 HGNC ID HGNC:12642 KEGG ID hsa:6843 NCBI Gene ID 6843 - General References
- Archer BT 3rd, Ozcelik T, Jahn R, Francke U, Sudhof TC: Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73. [Article]
- Isenmann S, Khew-Goodall Y, Gamble J, Vadas M, Wattenberg BW: A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. Mol Biol Cell. 1998 Jul;9(7):1649-60. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
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- Bourassa CV, Meijer IA, Merner ND, Grewal KK, Stefanelli MG, Hodgkinson K, Ives EJ, Pryse-Phillips W, Jog M, Boycott K, Grimes DA, Goobie S, Leckey R, Dion PA, Rouleau GA: VAMP1 mutation causes dominant hereditary spastic ataxia in Newfoundland families. Am J Hum Genet. 2012 Sep 7;91(3):548-52. doi: 10.1016/j.ajhg.2012.07.018. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Botulinum toxin type B approved, investigational yes target binder Details