Vesicle-associated membrane protein 2
Details
- Name
- Vesicle-associated membrane protein 2
- Kind
- protein
- Synonyms
- SYB2
- Synaptobrevin-2
- VAMP-2
- Gene Name
- VAMP2
- UniProtKB Entry
- P63027Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0016692|Vesicle-associated membrane protein 2 MSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKL SELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST
- Number of residues
- 116
- Molecular Weight
- 12662.585
- Theoretical pI
- 8.48
- GO Classification
- Processescalcium-ion regulated exocytosis / protein-containing complex assembly / SNARE complex assembly / synaptic vesicle endocytosisComponentsclathrin-coated endocytic vesicle membrane
- General Function
- Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1
- Specific Function
- calcium-dependent protein binding
- Pfam Domain Function
- Synaptobrevin (PF00957)
- Signal Regions
- Not Available
- Transmembrane Regions
- 95-114
- Cellular Location
- Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
- Gene sequence
>lcl|BSEQ0016693|Vesicle-associated membrane protein 2 (VAMP2) ATGTCTGCTACCGCTGCCACGGCCCCCCCTGCTGCCCCGGCTGGGGAGGGTGGTCCCCCT GCACCCCCTCCAAACCTCACCAGTAACAGGAGACTGCAGCAGACCCAGGCCCAGGTGGAT GAGGTGGTGGACATCATGAGGGTGAACGTGGACAAGGTCCTGGAGCGAGACCAGAAGCTG TCGGAGCTGGACGACCGTGCAGATGCACTCCAGGCGGGGGCCTCCCAGTTTGAAACAAGC GCAGCCAAGCTCAAGCGCAAATACTGGTGGAAAAACCTCAAGATGATGATCATCTTGGGA GTGATTTGCGCCATCATCCTCATCATCATCATAGTTTACTTCAGCACTTAA
- Chromosome Location
- 17
- Locus
- 17p13.1
- External Identifiers
Resource Link UniProtKB ID P63027 UniProtKB Entry Name VAMP2_HUMAN GenBank Protein ID 338632 GenBank Gene ID M36205 GeneCard ID VAMP2 GenAtlas ID VAMP2 HGNC ID HGNC:12643 PDB ID(s) 3FIE, 3FII, 3RK2, 3RK3, 3RL0, 7UDC KEGG ID hsa:6844 NCBI Gene ID 6844 - General References
- Archer BT 3rd, Ozcelik T, Jahn R, Francke U, Sudhof TC: Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. J Biol Chem. 1990 Oct 5;265(28):17267-73. [Article]
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- Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW: Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. Biochem J. 1996 Aug 1;317 ( Pt 3):945-54. [Article]
- Kutay U, Ahnert-Hilger G, Hartmann E, Wiedenmann B, Rapoport TA: Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. EMBO J. 1995 Jan 16;14(2):217-23. [Article]
- Fritzius T, Frey AD, Schweneker M, Mayer D, Moelling K: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. FEBS J. 2007 Mar;274(6):1552-66. [Article]
- Hanson MA, Stevens RC: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution. Nat Struct Biol. 2000 Aug;7(8):687-92. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Botulinum toxin type B approved, investigational yes target binder Details