Vesicle-associated membrane protein 2

BE0002137ProteinHumansVAMP2

SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. It is acted on by 1 drug in DrugBank.

Gene name
VAMP2
UniProtKB entry
P63027Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Residues / weight
116 residues · 12,663 Da
Also known as
SYB2 · Synaptobrevin-2 · VAMP-2

Resolves to

Protein
UniProtP63027UniProt nameVAMP2_HUMAN
Gene
HGNCHGNC:12643NCBI Gene6844GenBank338632GeneCardsVAMP2
Pharmacology
KEGGhsa:6844
Structure
PDB3FIEPDB3FIIPDB3RK2
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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45GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vesicle-associated membrane protein 2, how selective are they, and which programs against it are still in active trials?

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