SPARC

BE0002145ProteinHumansSPARC

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. It is acted on by 3 drugs in DrugBank.

Gene name
SPARC
UniProtKB entry
P09486Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Residues / weight
303 residues · 34,632 Da
Also known as
Basement-membrane protein 40 · BM-40 · ON · Osteonectin · Secreted protein acidic and rich in cysteine

Resolves to

Protein
UniProtP09486UniProt nameSPRC_HUMAN
Gene
HGNCHGNC:11219NCBI Gene6678GenBank29462GeneCardsSPARC
Pharmacology
KEGGhsa:6678
Structure
PDB1BMOPDB1NUBPDB1SRA
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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17Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on SPARC, how selective are they, and which programs against it are still in active trials?

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