Prolyl endopeptidase

BE0002148ProteinHumansPREP

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. It is acted on by 11 drugs in DrugBank.

Gene name
PREP
UniProtKB entry
P48147Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
710 residues · 80,699 Da
Also known as
3.4.21.26 · PE · PEP · Post-proline cleaving enzyme

Resolves to

Protein
UniProtP48147UniProt namePPCE_HUMAN
Gene
HGNCHGNC:9358NCBI Gene5550GenBank558596GeneCardsPREP
Pharmacology
IUPHAR/GtoPdb2395KEGGhsa:5550
Structure
PDB3DDUPDB9Q5GPDB9Q5X
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolyl endopeptidase, how selective are they, and which programs against it are still in active trials?

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