5-aminolevulinate synthase

BE0002158ProteinHumansALAS1

Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. It is acted on by 1 drug in DrugBank.

Gene name
ALAS1
UniProtKB entry
Q5JAM2TrEMBL
Cellular location
Mitochondrion matrix
Residues / weight
640 residues · 70,580 Da
Also known as
2.3.1.37 · 5-aminolevulinic acid synthase · Delta-ALA synthase · Delta-aminolevulinate synthase

Resolves to

Protein
UniProtQ5JAM2UniProt nameQ5JAM2_HUMAN
Gene
NCBI Gene211GenBank33112016
Pharmacology
KEGGhsa:211
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-aminolevulinate synthase, how selective are they, and which programs against it are still in active trials?

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