Cyanocobalamin reductase / alkylcobalamin dealkylase

BE0002175ProteinHumansMMACHC

Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). It is acted on by 2 drugs in DrugBank.

Gene name
MMACHC
UniProtKB entry
Q9Y4U1Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
282 residues · 31,728 Da
Also known as
Alkylcobalamin:glutathione S-alkyltransferase · CblC · Cyanocobalamin reductase (cyanide-eliminating) · Methylmalonic aciduria and homocystinuria type C protein · MMACHC

Resolves to

Protein
UniProtQ9Y4U1UniProt nameMMAC_HUMAN
Gene
HGNCHGNC:24525NCBI Gene25974GenBank52545527GeneCardsMMACHC
Pharmacology
KEGGhsa:25974
Structure
PDB3SBYPDB3SBZPDB3SC0
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
2GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
19+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cyanocobalamin reductase / alkylcobalamin dealkylase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In