Methionine adenosyltransferase 2 subunit beta

BE0002178ProteinHumansMAT2B

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. It is acted on by 1 drug in DrugBank.

Gene name
MAT2B
UniProtKB entry
Q9NZL9Swiss-Prot
Residues / weight
334 residues · 37,552 Da
Also known as
MAT II beta · Methionine adenosyltransferase II beta · Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase · TGR

Resolves to

Protein
UniProtQ9NZL9UniProt nameMAT2B_HUMAN
Gene
HGNCHGNC:6905NCBI Gene27430GenBank6815285GeneCardsMAT2B
Pharmacology
KEGGhsa:27430
Structure
PDB2YDXPDB2YDYPDB4KTT
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methionine adenosyltransferase 2 subunit beta, how selective are they, and which programs against it are still in active trials?

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