Peptidyl-glycine alpha-amidating monooxygenase

BE0002200ProteinHumansPAM

Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). It is acted on by 6 drugs in DrugBank.

Gene name
PAM
UniProtKB entry
P19021Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle membrane
Residues / weight
973 residues · 108,331 Da
Also known as
PAM

Resolves to

Protein
UniProtP19021UniProt nameAMD_HUMAN
Gene
HGNCHGNC:8596NCBI Gene5066GenBank189595GeneCardsPAM
Pharmacology
KEGGhsa:5066
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidyl-glycine alpha-amidating monooxygenase, how selective are they, and which programs against it are still in active trials?

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