DNA oxidative demethylase ALKBH2

BE0002205ProteinHumansALKBH2

Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. It is acted on by 1 drug in DrugBank.

Gene name
ALKBH2
UniProtKB entry
Q6NS38Swiss-Prot
Cellular location
Nucleus
Residues / weight
261 residues · 29,322 Da
Also known as
1.14.11.33 · ABH2 · Alkylated DNA repair protein alkB homolog 2 · Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 · Oxy DC1

Resolves to

Protein
UniProtQ6NS38UniProt nameALKB2_HUMAN
Gene
HGNCHGNC:32487NCBI Gene121642GenBank53988530GeneCardsALKBH2
Pharmacology
KEGGhsa:121642
Structure
PDB3BTXPDB3BTYPDB3BTZ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA oxidative demethylase ALKBH2, how selective are they, and which programs against it are still in active trials?

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